SFB889 Cellular Mechanisms of Sensory Processing

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Im Institut für Auditorische Neurowissenschaften ist zum nächstmöglichen Termin im Verwaltungsdienst des Sonderforschungsbereichs (SFB) 889 "Zelluläre Mechanismen sensorischer Verarbeitung" folgende Stelle zu besetzen:

Administrativer Koordinator (w/m)


- Entgelt nach TV-L (befristet bis zum 31.12.2022 gemäß der Förderperiode des SFB 889, Vollzeit, 38,5 Std./Wo.) -

zur Unterstützung des SFB 889 bei Mittelverwaltung, Beschaffungen, Personalmaßnahmen sowie Vortrags- und Kursveranstaltungen, Gastwissenschaftler-Aufenthalten, Erstellung von Berichten und Anträgen sowie Pflege des Webauftritts.

Die Universitätsmedizin Göttingen (UMG) umfasst die Medizinische Fakultät und das Universitätsklinikum. Mit über 7.700 Mitarbeiterinnen und Mitarbeitern ist die UMG der größte Arbeitgeber in der Region. Mehr als 65 Kliniken, Institute und Abteilungen stehen für eine qualitativ hochwertige Patientenversorgung, exzellente Forschung und moderne Lehre. Göttingen als Stadt der Wissenschaft liegt im Zentrum Deutschlands und die Universitätsmedizin ist vor Ort eingebunden in ein attraktives Netzwerk universitärer und außeruniversitärer Wissenschaftseinrichtungen.

Zu den Aufgaben gehören die Unterstützung bei der administrativen Koordination des SFB 889 „Zelluläre Mechanismen sensorischer Verarbeitung“ inklusive Mittelverwaltung, Beschaffungen, Vorbereitung von Personalmaßnahmen sowie von Vortrags- und Kursveranstaltungen, Unterstützung von Gastwissenschaftler-Aufenthalten, Unterstützung bei der Erstellung von Berichten und Anträgen sowie der Pflege des Webauftritts des SFB889. Weitere Tätigkeiten sind die Mitorganisation der Aktivitäten des sensorischen Schwerpunkts der Universität Göttingen und die Mitbetreuung des „Sensory and Motor Neuroscience“ Promotionsprogramms der Graduiertenschule GGNB.

Gute englische Sprachkenntnisse in Wort und Schrift sind für die Arbeit erforderlich. SAP-Grundkenntnisse und Kenntnisse in der Drittmittelverwaltung wären wünschenswert.

Die Universitätsmedizin Göttingen strebt in den Bereichen, in denen Männer unterrepräsentiert sind, eine Erhöhung des Männeranteils an und fordert daher qualifizierte Männer ausdrücklich zur Bewerbung auf. Schwerbehinderte Bewerberinnen/Bewerber werden bei gleicher Eignung bevorzugt berücksichtigt.

Ihre Bewerbung richten Sie bitte bis zum 05.01.2019 an:

Universitätsmedizin Göttingen
Institut für Auditorische Neurowissenschaften
Herrn Prof. Tobias Moser
Institutsleiter, Sprecher des SFB 889
37099 Göttingen
Tel.: 0551/39-63071
Fax: 0551/39-22299
E-Mail: ianoff@gwdg.de

Ihre Ansprechpartner
Dr. Jakob Neef, Tel.: 0551/39-61949, jneef@gwdg.de
oder
Susann Müller, Tel.: 0551/39-61942, sfb889@med.uni-goettingen.de

Fahrt- und Bewerbungskosten können nicht erstattet oder übernommen werden.

Bitte reichen Sie Ihre Bewerbungsunterlagen ausschließlich per E-Mail im PDF-Format ein.

Druckversion Stellenanzeige



The Institute for Auditory Neuroscience of the University Medical Center Göttingen (Germany) invites applications for a

PhD student position in Synaptic Neuroscience

Mammalian sound encoding relies on faithful and precise neurotransmission between cochlear inner hair cells (IHC) and afferent spiral ganglion neurons. To master this challenging task, the presynaptic active zones of IHCs are equipped with presynaptic specializations –termed 'synaptic ribbons' – that facilitate high rates of vesicular release and subsequent replenishment, even during prolonged periods of ongoing stimulation. While the molecular architecture and function of ribbon-type active zones has been an area of intense research, the presynaptic development prior to hearing onset still remains largely enigmatic. Hence, this project will focus on developmental aspects of IHC pre-synaptogenesis in auditory hair cells and aims to identify the key molecules, as well as the underlying cellular processes that determine the functional maturation and presynaptic plasticity of this high-throughput synapse.
The successful candidate will be tightly integrated within the Institute for Auditory Neuroscience (University Medical Center) and the III. Physical Institute (Georg August University). The project will employ various gene manipulation approaches in combination with electrophysiology, optogenetics and advanced light-microscopic imaging techniques (e.g. live-cell wide-field, confocal and stimulated emission depletion [STED] microscopy) to decipher molecular determinants of presynaptic active zone formation and maturation in acutely dissected or cultured mammalian inner ear preparations.
We are looking for highly motivated applicants with a strong background in neuroscience and/or live-cell imaging; additional experience in molecular biology or programming skills are of advantage. Moreover, the ability to work in an interdisciplinary (i.e. combining molecular, ultrastructural and physiological approaches) and international research team is an essential prerequisite. This position is supported by a DFG Grant (Collaborative Research Center 889) and the funding will be available for 3.5 years. Income is equivalent to E13/65%.
Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.
The Göttingen Campus is a leading Neuroscience Center hosting numerous internationally renowned research institutions. This includes the University and its Medical Center, three Max Planck Institutes, the European Neuroscience Institute, and the German Primate Center. The Institute for Auditory Neuroscience & InnerEarLab offers a stimulating multidisciplinary research and training environment and operates state of the art research infrastructure. Moreover, the institute is tightly integrated in the Campus with research groups hosted also at non-university institutions and runs numerous productive collaborations on Campus such as within the collaborative sensory research center 889 (www.sfb889.uni-goettingen.de), the Bernstein Center for Computational Neuroscience (BCCN, www.bccn-goettingen.de) and the Center for Nanoscale Microscopy and Molecular Physiology of the Brain (www.cmpb.uni-goettingen.de) as well as beyond the Campus.

Please submit your application preferably in one single PDF-document, including cover letter, CV, list of publications, names of possible referees, and relevant certificates to: christian.vogl@med.uni-goettingen.de until January 31st, 2019.

Dr. Christian Vogl
Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
Robert-Koch-Str. 40, D-37075 Goettingen, Germany



The Institute for Auditory Neuroscience of the University Medical Center Göttingen (Germany) invites applications for a

PhD student position in synaptic mechanisms of noise-induced hearing loss

Sound is encoded at the ribbon synapses of the cochlear inner hair cells. These cells, together with the postsynaptic auditory terminals, are very fragile and can be injured and/or lost following exposure to noise, ototoxic drugs, and also in the process of aging. Such injury usually results in permanent hearing loss and affects millions of people around the world. The project will aim at identifying the processes that underlie the noise-induced damage to the hair cells of the inner ear. The successful candidate will investigate synaptic mechanisms of noise-induced hearing loss and potential novel therapeutic approaches for the treatment of such hearing loss. Work will use optogenetic tools and include state of the art electrophysiology (presynaptic patchclamp recordings), optical methods (confocal/STED imaging of fluorescent probes in fixed and live tissue, calcium imaging), systems physiology tests and immunohistochemistry.
We are looking for excellent and highly motivated applicants with a strong background (first degree) in physics or biology, preferably with prior experience in biophysics or electrophysiology. The ability to work in an interdisciplinary and international team of researchers is required.
The funding of the candidate’s PhD research will be supported by the collaborative sensory research center SFB889 (www.sfb889.uni-goettingen.de). Göttingen is world renowned for its research in neuroscience. It is a stimulating and highly collaborative scientific environment hosting numerous prestigious and internationally renowned neuroscience research institutions, such as Georg-August-University, three relevant Max Planck Institutes, University Medical Center Göttingen (UMG), German Primate Center (DPZ) and European Neuroscience Institute (ENI). Funding is available for 3.5 years. The salary is according to TV-L (65%).
Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

We look forward to receiving your application by January 31st, 2019:
University Medical Center Göttingen
Institut für Auditorische Neurowissenschaften
Tina Pangrsic Vilfan
Group Leader Synaptic physiology of mammalian vestibular hair cells
37099 Göttingen
Tel.: 0551/39-61945
Fax: 0551/39-61957
E-Mail: tpangrs@gwdg.de
Web: http://www.auditory-neuroscience.uni-goettingen.de

Please send your application only via e-mail as a PDF-file.
Travel and application fees cannot be refunded or transferred.



In the 3rd funding period of CRC 889, the Department of Otolaryngology, Institute of Auditory Neuroscience, and Inner Ear Lab offer an attractive

PhD student position in Auditory Systems Physiology

The successful candidate will study the disease mechanisms of human hearing loss using genetically modified mouse lines that carry mutations implicated in human deafness. We focus on the question how sound encoding in the auditory nerve and sound perception are changed when the organ of Corti and specifically the inner hair cell ribbon synapse do not function normally. With a direct link to the clinical department, our aim is to better understand normal and impaired hearing function and to improve diagnostic techniques and hearing rehabilitation strategies.
The experimental work of the project will consist of in vivo recordings from the rodent auditory system, including challenging extracellular single neuron recordings from the auditory nerve, as well as immunohistochemical staining on preparations of the Organ of Corti. Potentially, behavioral assessments of hearing function will also be used. All techniques are generally established in the lab.
Previous experience with electrophysiological experiments, microsurgery and/or a completed course on animal experimentation (FELASA B) will be useful. In addition, experience with immunohistochemical staining procedures and confocal or STED imaging, as well as technical knowledge and programming skills, ideally in Python and/or Matlab, will be helpful. Applicants should hold a Master’s degree or equivalent in neuroscience, audiology, physiology, animal biology or molecular medicine, ideally with a focus on sensory physiology. The ability to work in an interdisciplinary, English-speaking international team of researchers is required.
The Göttingen Campus is a leading Neuroscience Center hosting numerous prestigious and internationally renowned research institutions. This includes the University and its Medical Center, three life science Max Planck Institutes, the European Neuroscience Institute, and the German Primate Center. The Auditory Systems Physiology group is part of the InnerEarLab (http://www.innerearlab.uni-goettingen.de), consisting of 7 groups employing molecular, structural, physiological, and theoretical approaches to study inner ear function. Most PhD students are enrolled in the „sensory and motor neuroscience“ or “systems neuroscience” programs of the Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB, http://www.uni-goettingen.de/en/sh/56640.html).
Funding is available for 3.5 years. The salary is according to TV-L (65%).
Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

We look forward to receiving your application by January 15th, 2019:
University Medical Center Göttingen
Department of Otolaryngology
Nicola Strenzke
Group Leader Synaptic physiology of mammalian vestibular hair cells
37099 Göttingen
Tel.: 0551/39-9688
Fax: 0551/39-61957
E-Mail: nicola.strenzke@med.uni-goettingen.de
Web: http://www.innerearlab.uni-goettingen.de

Please send your application via e-mail preferably in one single PDF-document, including cover letter, CV, list of publications, names of possible referees, and relevant certificates.
Travel and application fees cannot be refunded or transferred.



PhD student position in Biochemistry, Neurobiology, Molecular Biology or a related life science subject

The Group for Molecular Biology of Cochlear Neurotransmission within the Department for Otorhinolaryngology is offering a position for a PhD student in the field of

Biochemistry, Neurobiology, Molecular Biology or a related life science subject.

The position with 65% of the regular working time will start as soon as possible and initially lasts for three years. The salary is according to TV-L (65%).

Your Profile:
Applicants are expected to have completed university studies in a life science discipline and should have a strong background in biochemistry, molecular biology, neurosciences, molecular medicine and/or biophysics. Practical experience in molecular biology such as cloning, in protein biochemistry, in cell culture work, in immunohistochemistry and in electrophysiology would be beneficial. Very good English skills for oral and written presentations are expected.
The InnerEarLab is an internationally highly recognized lab for studying the signal transduction from sensory hair cells of the inner ear to subsequent neurons. We use molecular manipulation and electrophysiology to elucidate the function of inner hair cells, the hair cell synapses and the sound encoding in the auditory nerve in wild type and mutant mice. These techniques include single cell quantitative PCR, protein biochemistry, recordings of the postsynaptic boutons as well as single unit recordings of the auditory nerve.
The position will be part of the Molecular Biology of Cochlear Neurotransmission Research Group of Dr. Ellen Reisinger and is financed by the German Research Foundation (DFG) within the collaborative research consortium (SFB) 889, project A4. The group is interested in the molecular mechanism of hair cell exocytosis with a focus on the function and regulation of otoferlin, which is defective in a form of human deafness (e.g. Pangrsic et al., Nat Neurosci 2010; Helfmann et al., J. Mol Biol 2011; Reisinger et al. J. Neuroscience 2011). In the current project, we aim to study protein interactions and posttranslational modifications of otoferlin using molecular biology, cell culture, biochemical, immunohistochemical and electrophysiological methods.
Women are especially encouraged to apply. Handicapped applicants with equal qualifications will be given preferential treatment.
We look forward to receiving your application by June 15th 2015.
Please send your applications as a single pdf file to

Dr. Ellen Reisinger
Ellen.reisinger@medizin.uni-goettingen.de


DFG - Deutsche ForschungsgemeinschaftGeorg-August-Universität Göttingen