SFB889 Cellular Mechanisms of Sensory Processing

Jobs

Currently we do not have open positions.





The Collaborative Research Center 889 invites applications for a

Research Rotation for Clinicians (“Gerok-Stelle”)

to perform research on sensory systems in the frame of the Collaborative Research Center 889. CRC 889 explores the cellular mechanisms of sensory processing in a wide range of sensory systems and animal models using state-of-the-art methods. Research rotations can be either performed as part of one of the groups of CRC 889 or as an independent project working on a related topic and typically last for 6-12 months. During this time, the salary of the clinician scientist will be covered by CRC 889. No additional funds for consumables, travel, or personnel are available.

If you are a clinician who is interested in performing research on sensory systems, please send a short description of your project along with your CV as a single pdf file to jneef@gwdg.de by February 28th, 2019.

Dr. Jakob Neef
Scientific Coordinator CRC 889
Auditory Neuroscience Group
Max Planck Institute of Experimental Medicine
Hermann Rein Str. 3
37075 Göttingen, Germany
Tel.: +49 551/39-61949
E-Mail: jneef@gwdg.de



The Institute for Auditory Neuroscience of the University Medical Center Göttingen (Germany) invites applications for a

PhD student position in Synaptic Neuroscience

Your profile:

  • - Strong background in sensory neuroscience
  • - Experience in electron microscopy advantageous
  • - Excellent English skills
  • - Completed university studies in a life science discipline (MSc or diploma)
  • Cochlear inner hair cell (IHC) ribbon synapses are specialized structures that are crucial for the conversion of acoustical information into neural signals. Defects in transmission cause hearing impairment – auditory synaptopathy. We investigate the dynamic nanostructure of synaptic vesicle pools at ribbon synapses in IHCs of wild-type and mutant mice. In the proposed project, we analyze exocytosis phases at IHC ribbon synapses by the usage of temporally precise stimulation through optogenetics. This we will combine with high-pressure freezing (HPF)/freeze-substitution and subsequent electron tomography. We will precisely stimulate IHCs of channelrhodopsin2 mice crossbred with KOs for different presynaptic key players in order to understand the influence of these different presynaptic proteins in parameters such as synaptic vesicle number or how they are linked to the active zone.

    The offered PhD project is founded by the German Research Foundation (DFG, CRC 889, “Cellular Mechanisms of Sensory Processing”) and is part of the Molecular Architecture of Synapses Research Group of the Institute for Auditory Neuroscience at the Center for Biostructural Imaging of Neurodegeneration (BIN). The position is available for 3+ years. Income is equivalent to E13/65%.

    The Göttingen Campus is a leading neuroscience center in Europe hosting numerous prestigious and internationally renowned neuroscience research institutions. This includes the University, three Max Planck Institutes, the European Neuroscience Institute and the German Primate Center, as well as further collaborative research programs.

    Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.


    We look forward to receiving your application by March 6th, 2019:

    University Medical Center Göttingen
    Institut für Auditorische Neurowissenschaften
    Carolin Wichmann
    37099 Göttingen
    Phone: +49 551 39 61128
    Fax: +49 551 39 12950
    Email: carolin.wichmann@med.uni-goettingen.de
    Web: http://www.auditory-neuroscience.uni-goettingen.de
    Please send your application only via e-mail as a PDF-file.
    Travel and application fees cannot be refunded or transferred.



    The Institute for Auditory Neuroscience @ Max Planck Institute of Experimental Medicine, Göttingen (Germany) invites applications for a

    PhD student position in the Molecular Physiology of Hair Cell Ribbon Synapses

    The successful candidate will conduct experimental research on the molecular anatomy and physiology of synaptic transmission at the inner hair cell synapses of the auditory pathway. Using state of the art electrophysiology (pre- and/or postsynaptic patch-clamp, capacitance measurements) and optical methods (uncaging, confocal, and STED imaging) in combination with genetically manipulated animals, the project targets a fundamental question in synaptic transmission and sound encoding: What are the synaptic mechanisms diversifying the neural code in the cochlea?
    We are looking for excellent and highly motivated applicants with a strong background (first degree) in physics, biology or neuroscience and, ideally, experience in biophysical techniques. Competence in electrophysiology and state of the art light microscopy will be useful. Good computational skills and the ability to work in an interdisciplinary (combining molecular, structural, physiological and theoretical approaches) and international team of researchers are required. Prior knowledge in theoretical neuroscience is welcome.
    This position is supported by a DFG Grant (Collaborative Research Center 889) and the funding will be available for 3.5 years. Income is equivalent to E13/65%.
    The Göttingen Campus is a leading neuroscience center in Europe hosting numerous prestigious and internationally renowned neuroscience research institutions. This includes the University, three Max Planck Institutes, the European Neuroscience Institute and the German Primate Center, as well as further collaborative research programs.
    Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

    Please submit your application preferably in one single PDF document, including cover letter, CV, list of publications (if applicable), names of possible referees, and relevant certificates to ianoff@gwdg.de until February 15th, 2019.

    Prof. Dr. Tobias Moser
    Professor of Auditory Neuroscience
    Auditory Neuroscience Group
    Max Planck Institute of Experimental Medicine
    Hermann Rein Str. 3
    Göttingen, Germany
    E-Mail: ianoff@gwdg.de
    Websites: http://www.auditory-neuroscience.uni-goettingen.de
    http://www.em.mpg.de/index.php?id=373&tx_jppageteaser_pi1%5BbackId%5D=16
    http://www.sfb889.uni-goettingen.de/

    Travel and application fees cannot be refunded or transferred.




  • Im Institut für Auditorische Neurowissenschaften ist zum nächstmöglichen Termin im Verwaltungsdienst des Sonderforschungsbereichs (SFB) 889 "Zelluläre Mechanismen sensorischer Verarbeitung" folgende Stelle zu besetzen:

    Administrativer Koordinator (w/m)


    - Entgelt nach TV-L (befristet bis zum 31.12.2022 gemäß der Förderperiode des SFB 889, Vollzeit, 38,5 Std./Wo.) -

    zur Unterstützung des SFB 889 bei Mittelverwaltung, Beschaffungen, Personalmaßnahmen sowie Vortrags- und Kursveranstaltungen, Gastwissenschaftler-Aufenthalten, Erstellung von Berichten und Anträgen sowie Pflege des Webauftritts.

    Die Universitätsmedizin Göttingen (UMG) umfasst die Medizinische Fakultät und das Universitätsklinikum. Mit über 7.700 Mitarbeiterinnen und Mitarbeitern ist die UMG der größte Arbeitgeber in der Region. Mehr als 65 Kliniken, Institute und Abteilungen stehen für eine qualitativ hochwertige Patientenversorgung, exzellente Forschung und moderne Lehre. Göttingen als Stadt der Wissenschaft liegt im Zentrum Deutschlands und die Universitätsmedizin ist vor Ort eingebunden in ein attraktives Netzwerk universitärer und außeruniversitärer Wissenschaftseinrichtungen.

    Zu den Aufgaben gehören die Unterstützung bei der administrativen Koordination des SFB 889 „Zelluläre Mechanismen sensorischer Verarbeitung“ inklusive Mittelverwaltung, Beschaffungen, Vorbereitung von Personalmaßnahmen sowie von Vortrags- und Kursveranstaltungen, Unterstützung von Gastwissenschaftler-Aufenthalten, Unterstützung bei der Erstellung von Berichten und Anträgen sowie der Pflege des Webauftritts des SFB889. Weitere Tätigkeiten sind die Mitorganisation der Aktivitäten des sensorischen Schwerpunkts der Universität Göttingen und die Mitbetreuung des „Sensory and Motor Neuroscience“ Promotionsprogramms der Graduiertenschule GGNB.

    Gute englische Sprachkenntnisse in Wort und Schrift sind für die Arbeit erforderlich. SAP-Grundkenntnisse und Kenntnisse in der Drittmittelverwaltung wären wünschenswert.

    Die Universitätsmedizin Göttingen strebt in den Bereichen, in denen Männer unterrepräsentiert sind, eine Erhöhung des Männeranteils an und fordert daher qualifizierte Männer ausdrücklich zur Bewerbung auf. Schwerbehinderte Bewerberinnen/Bewerber werden bei gleicher Eignung bevorzugt berücksichtigt.

    Ihre Bewerbung richten Sie bitte bis zum 05.01.2019 an:

    Universitätsmedizin Göttingen
    Institut für Auditorische Neurowissenschaften
    Herrn Prof. Tobias Moser
    Institutsleiter, Sprecher des SFB 889
    37099 Göttingen
    Tel.: 0551/39-63071
    Fax: 0551/39-22299
    E-Mail: ianoff@gwdg.de

    Ihre Ansprechpartner
    Dr. Jakob Neef, Tel.: 0551/39-61949, jneef@gwdg.de
    oder
    Susann Müller, Tel.: 0551/39-61942, sfb889@med.uni-goettingen.de

    Fahrt- und Bewerbungskosten können nicht erstattet oder übernommen werden.

    Bitte reichen Sie Ihre Bewerbungsunterlagen ausschließlich per E-Mail im PDF-Format ein.

    Druckversion Stellenanzeige






  • In the 3rd funding period of CRC 889, the Department of Otolaryngology, Institute of Auditory Neuroscience, and Inner Ear Lab offer an attractive

    PhD student position in Auditory Systems Physiology

    The successful candidate will study the disease mechanisms of human hearing loss using genetically modified mouse lines that carry mutations implicated in human deafness. We focus on the question how sound encoding in the auditory nerve and sound perception are changed when the organ of Corti and specifically the inner hair cell ribbon synapse do not function normally. With a direct link to the clinical department, our aim is to better understand normal and impaired hearing function and to improve diagnostic techniques and hearing rehabilitation strategies.
    The experimental work of the project will consist of in vivo recordings from the rodent auditory system, including challenging extracellular single neuron recordings from the auditory nerve, as well as immunohistochemical staining on preparations of the Organ of Corti. Potentially, behavioral assessments of hearing function will also be used. All techniques are generally established in the lab.
    Previous experience with electrophysiological experiments, microsurgery and/or a completed course on animal experimentation (FELASA B) will be useful. In addition, experience with immunohistochemical staining procedures and confocal or STED imaging, as well as technical knowledge and programming skills, ideally in Python and/or Matlab, will be helpful. Applicants should hold a Master’s degree or equivalent in neuroscience, audiology, physiology, animal biology or molecular medicine, ideally with a focus on sensory physiology. The ability to work in an interdisciplinary, English-speaking international team of researchers is required.
    The Göttingen Campus is a leading Neuroscience Center hosting numerous prestigious and internationally renowned research institutions. This includes the University and its Medical Center, three life science Max Planck Institutes, the European Neuroscience Institute, and the German Primate Center. The Auditory Systems Physiology group is part of the InnerEarLab (http://www.innerearlab.uni-goettingen.de), consisting of 7 groups employing molecular, structural, physiological, and theoretical approaches to study inner ear function. Most PhD students are enrolled in the „sensory and motor neuroscience“ or “systems neuroscience” programs of the Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB, http://www.uni-goettingen.de/en/sh/56640.html).
    Funding is available for 3.5 years. The salary is according to TV-L (65%).
    Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.


    Please send your application via e-mail preferably in one single PDF-document, including cover letter, CV, list of publications, names of possible referees, and relevant certificates:

    University Medical Center Göttingen
    Department of Otolaryngology
    Nicola Strenzke
    Group Leader Auditory Systems Physiology
    37099 Göttingen
    Tel.: 0551/39-9688
    Fax: 0551/39-61957
    E-Mail: nicola.strenzke@med.uni-goettingen.de
    Web: http://www.innerearlab.uni-goettingen.de

    Travel and application fees cannot be refunded or transferred.



    PhD student position in Biochemistry, Neurobiology, Molecular Biology or a related life science subject

    The Group for Molecular Biology of Cochlear Neurotransmission within the Department for Otorhinolaryngology is offering a position for a PhD student in the field of

    Biochemistry, Neurobiology, Molecular Biology or a related life science subject.

    The position with 65% of the regular working time will start as soon as possible and initially lasts for three years. The salary is according to TV-L (65%).

    Your Profile:
    Applicants are expected to have completed university studies in a life science discipline and should have a strong background in biochemistry, molecular biology, neurosciences, molecular medicine and/or biophysics. Practical experience in molecular biology such as cloning, in protein biochemistry, in cell culture work, in immunohistochemistry and in electrophysiology would be beneficial. Very good English skills for oral and written presentations are expected.
    The InnerEarLab is an internationally highly recognized lab for studying the signal transduction from sensory hair cells of the inner ear to subsequent neurons. We use molecular manipulation and electrophysiology to elucidate the function of inner hair cells, the hair cell synapses and the sound encoding in the auditory nerve in wild type and mutant mice. These techniques include single cell quantitative PCR, protein biochemistry, recordings of the postsynaptic boutons as well as single unit recordings of the auditory nerve.
    The position will be part of the Molecular Biology of Cochlear Neurotransmission Research Group of Dr. Ellen Reisinger and is financed by the German Research Foundation (DFG) within the collaborative research consortium (SFB) 889, project A4. The group is interested in the molecular mechanism of hair cell exocytosis with a focus on the function and regulation of otoferlin, which is defective in a form of human deafness (e.g. Pangrsic et al., Nat Neurosci 2010; Helfmann et al., J. Mol Biol 2011; Reisinger et al. J. Neuroscience 2011). In the current project, we aim to study protein interactions and posttranslational modifications of otoferlin using molecular biology, cell culture, biochemical, immunohistochemical and electrophysiological methods.
    Women are especially encouraged to apply. Handicapped applicants with equal qualifications will be given preferential treatment.
    We look forward to receiving your application by June 15th 2015.
    Please send your applications as a single pdf file to

    Dr. Ellen Reisinger
    Ellen.reisinger@medizin.uni-goettingen.de


    DFG - Deutsche ForschungsgemeinschaftGeorg-August-Universität Göttingen